Peripheral Arterial Insufficiency

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Cell culture To determine whether exogenous donor mitochondria can be taken up into neurons growing in culture, we co-cultured exogenous mitochondria extracted from the brain or muscle tissues of donor rats with neural cell cultures. Both donor mitochondria and recipient neural cell cultures were derived from male Sprague–Dawley rats (12 weeks old; Charles River Laboratories, Wilmington, MA, USA). Neural cells were isolated using the Adult Brain Dissociation kit (Miltenyi Biotec, Inc., Somerville, MA, USA). Cells were seeded at a density of 1 × 10 5 cells/cm 2 onto glass coverslips coated with poly- d -lysine (0.1 mg/mL). The endogenous (native) mitochondria of the cells were separately labeled 24 h before mitochondrial transfer with MitoTracker dye (Thermo Fisher Scientific, Waltham, MA, USA) according to the manufacturer's instructions. Briefly, the cells were suspended in a prewarmed (37 °C) staining solution containing the MitoTracker Green

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Today we're continuing our series on common newborn conditions. In my last column we talked about the sneezes, hiccups, gurgles, grunts and snorts these little creatures often make. Now we'll focus on newborn babies' appearance, including common skin ailments. At first glance some of these conditions may be alarming to new parents, but most are non-worrisome and par for the course in these little newbies. Skin is the largest organ in the human body, and as such it's one of the first things parents notice after baby is born or when their blanket is unwrapped. Immediately after birth, newborns' skin often appears pale or bluish, but quickly becomes pink in the first few minutes of life as their breathing becomes more regular and fluid is cleared from the lungs. Blue or purple discoloration of the hands and feet (termed "acrocyanosis") can persist for hours t

Symptoms of Ebola virus disease (EVD) start presenting anywhere from two to 21 days after exposure to the Ebola virus. Signs include the typical symptoms of a viral illness, such as fever, aches and pains, gastrointestinal issues, sore throat, and fatigue. Unexplained bleeding and bruising, red eyes, skin rash, and hiccups can also occur in the later stage of the illness. What Is Ebola? Ebola virus disease is a rare but serious and often fatal illness initially transmitted to humans from wild animals and then spread through person-to-person contact. Ebola cannot be spread before symptoms start. In this article, you'll learn more about the frequent symptoms and what to expect with EVD. You'll also get to know which rare symptoms to watch for, what Ebola complications exist, and when to see a healthcare provider for EVD symptoms. Catherine Falls Commercial / Getty Images Common Symptoms Ebola is rare, but the symptoms associate

Robert Bissonnette, MD, MSc Credit: Innovaderm Topical pan-JAK inhibitor drug candidate delgocitinib cream provided significant improvements across a series of clinical and patient-related outcomes for chronic hand eczema, according to new phase 3 data. 1 In findings presented during the late-breaking abstract sessions at the American Academy of Dermatology (AAD) 2023 Annual Meeting in New Orleans this weekend, investigators observed a doubled rate of patients achieving treatment success per Investigators Global Assessment scores (IGA-CHE) with deglocitinib versus vehicle cream at 16 weeks. Presented by Robert Bissonnette, MD, MSc, from Innodvaderm Research in Montreal, Quebec, the findings may support the regulatory development and possible approval of the LEO Pharma agent to treat the burdensome form of eczema. Bissonnette and colleagues sought to analyze the efficacy, safety and effect of twice-daily topical 20 mg delgocitinib on health-related quality of life versus vehicle cream i

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Abstract To investigate the effect and safety of recanalization surgery for non-acute occlusion of large intracranial arteries and factors affecting clincial outcomes. Patients with non-acute occlusion of internal carotid artery (ICA), middle cerebral artery (MCA), and vertebrobasilar artery (VBA) treated with recanalization were retrospectively enrolled. The clinical and angiographic data were analyzed. 177 patients were enrolled, including 67 patients with intracranial ICA occlusion, 52 with MCA occlusion, and 58 with VBA occlusion. Successful recanalization was achieved in 152 (85.9%) patients. Complications occurred in 15 patients (8.5%). Followed up for 3–7 months, the 90 day mRS was significantly improved compared with that before the procedure. Among 152 patients with successful recanalization, eight patients experienced reocclusion (5.3%), and 11 patients experienced restenosis (7.2%). Successful recanalization was significantly (P < 0.05) associated wi

Any products in this article have been selected editorially however if you buy something we mention, we may earn commission Dry shampoo is an absolute hair saviour for when you need to push back hair-washing by a day, or maybe even two - no judgement here, or you need to revive hair post gym or just from a restless night's sleep (we have some pretty amazing insomnia tips if you need them btw). And dry shampoo formulations have come on leaps and bounds over the last few years. Gone are the days of them making it look like you'd poured talc on your roots but on the flip side there is now so much choice it can be hard to know how to choose the best one for your hair type. We got celebrity hair stylist, Lewis Pallett to share his words of wisdom on all things dry shampoo related and have then put together an edit of the best dry shampoo out there. The do's and don'ts of dry shampoo Hair stylist Lewis Pallett shares how to pick the right dry shampoo for you and how