Peripheral Arterial Insufficiency

[unable to retrieve full-text content] Sex and Heart Disease: Is Sex Good for the Heart?    Health Central

Ossa Galvis MM, Bhakta RT, Tarmahomed A, Mendez MD. Cyanotic heart disease. StatPearls [Internet] . Updated: June 27, 2022. Treasure Island, FL: StatPearls Publishing. [QxMD MEDLINE Link]. [Full Text]. Rao PS. Diagnosis and management of cyanotic congenital heart disease: part I. Indian J Pediatr . 2009 Jan. 76(1):57-70. [QxMD MEDLINE Link]. Khairy P, Clair M, Fernandes SM, et al. Cardiovascular outcomes after the arterial switch operation for D-transposition of the great arteries. Circulation . 2013 Jan 22. 127(3):331-9. [QxMD MEDLINE Link]. [Full Text]. Nozica N, Asatryan B, Aur S, et al. Arrhythmias and clinical outcomes in a Swiss multicenter cohort of patients with dextro-transposition of the great arteries and atrial switch. J Am Heart Assoc . 2023 Jul 4. 12(13):e028956. [QxMD MEDLINE Link]. [Full Text]. Watanabe N, Mainwaring RD, Carrillo SA, Lui GK, Reddy VM, Hanley FL. Left ventricular retraining and late arterial switch for D-transposit

Share on Pinterest A simple blood test may be able to pick up on tell-tale signs of vascular problems in the brain, predicting stroke risk. Image credit: Douglas Sacha/Getty Images. A new study proposes a type of blood test for predicting cerebral small blood vessel disease and, thus, the likelihood of a stroke or cognitive decline in the future. The insight presented by the study is that people with high levels of five specific molecules in the interleukin-18 network are more likely to experience such events. More work is needed to validate the study's findings. While there is currently no cure for cerebral small blood vessel disease, experts suggest heart-healthy practices may help since the vessels are part of the cardiovascular system. A new study raises the possibility of a blood test that can predict the likelihood of having a stroke or experiencing cognitive decline in the future. The authors of the study identified a network of inflammatory molecules in the blood that allow

A recent research letter published in the journal Nature Cardiovascular Research describes two new genetic loci associated with coronary artery calcification (CAC). CAC is a measure of atherosclerosis and predicts coronary artery disease (CAD) events. Coronary calcification is a manifestation of atherosclerotic plaque. It is suggested to contribute to plaque rupture when present as microcalcifications, while more extensive calcification sheets are associated with stabilizing the plaque. Vascular calcification is characterized by the contractile-to-osteogenic phenotype switch of vascular smooth muscle cells (VSMCs). The osteogenic phenotype is characterized by the expression of markers, including the master regulator of the switch, Runt-related transcription factor 2 (RUNX2), and others such as alkaline phosphatase (ALPL) and bone gamma-carboxyglutamate protein (BGLAP). Genome-wide association studies (GWASs) have identified more than 200 loci associated with CAD events and

Abstract Theoretically pulse wave velocity (PWV) is obtained by calculating the distance between two waveform probes divided by the time difference, and PWV ratio is used to assess the arterial stiffness gradient (SG) from proximal to distal. The aim was to investigate segmental upper-limb PWV (ulPWV) differences and the effects of hypertension and or aging on each ulPWV and SG. The study collected multi-waveform signals and conduction distances from 167 healthy individuals and 92 hypertensive patients. The results showed significant differences between ulPWVs ( P  < 0.001), with increased and then decreased vascular stiffness along the proximal transmission to the distal peripheral artery and then to the finger. Adjusted for age and sex, ulPWVs in hypertension exceeded that of healthy individuals, with significant differences between groups aged ≥ 50 years ( P  < 0.05). The hrPWV/rfPWV (heart-radial/radial-finger) was reduced in hypertension and differed signifi

Abstract Experimental evidence indicates that follicle-stimulating hormone (FSH), an essential hormone for reproduction, can act directly on endothelial cells inducing atherosclerosis activation and development. However, it remains unknown whether the FSH-receptor (FSHR) is expressed in human atherosclerosis plaques. To demonstrate the FSHR presence, we used immunohistochemical and immunoelectron microscopy involving a specific monoclonal antibody FSHR1A02 that recognizes an epitope present in the FSHR-ectodomain. In all 55 patients with atherosclerotic plaques located in carotid, coronary, femoral arteries, and iliac aneurysm, FSHR was selectively expressed in arterial endothelium covering atherosclerotic plaques and endothelia lining intraplaque neovessels. Lymphatic neovessels were negative for FSHR. M1-macrophages, foam cells, and giant multinucleated cells were also FSHR-positive. FSHR was not detected in normal internal thoracic artery. Immunoelectron microscopy performed in ApoE