Multimodality imaging in the diagnostic management of concomitant aortic stenosis and transthyretin-related wild-type ... - Frontiers
Introduction Severe aortic stenosis (AS) is the most common valvular heart disease with a prevalence rate of more than 4% in 75-year-old people or older (1). In postmortem studies (2, 3), cardiac amyloidosis (CA), especially "wild-type transthyretin" (ATTRwt), has shown a prevalence rate ranging from 22% to 25% in people older than 80 years, with a predominance for male patients. The detection of the concomitant presence of CA and AS is seeing an increase because of new available diagnostic tools. However, the diagnostic process is challenging primarily because of the similar type of changes in the left ventricle (LV) structure and function caused by AS and CA, which share some morphological characteristics (4). Diagnostic management of these conditions appears critical, as it has been shown that the association of AS and CA increases the risk of mortality, especially because both pathologies are associated with heart failure (HF) development (5–8). In a case series, ATTR