Peripheral Arterial Insufficiency

FRIDAY, May 3, 2024 (HealthDay News) -- Peripheral artery disease (PAD) involves a debilitating narrowing of arteries in the legs, and the National Institutes of Health estimates that 1 in every 20 Americans over 50 is affected. Research into best treatments for women with PAD is lacking, however.  Now, a study finds that less invasive endovascular treatments work equally well in women as in men. Endovascular therapies -- minimally invasive procedures such as angioplasty or stenting -- help restore blood flow without the risks of more invasive procedures such as bypass.   The new study, led by Dr. Serdar Farhan of the Icahn School of Medicine at Mount Sinai in New York City, found these procedures benefited both sexes equally. The news has been a long time coming, he said. "While the findings of the study are of value considering the scarce data on PAD treatment in women, they are also a strong reminder that we must do better in enrolling women in PAD trials,&quo

Abstract Localization of early infarction on first-line Non-contrast computed tomogram (NCCT) guides prompt treatment to improve stroke outcome. Our previous study has shown a good performance in the identification of ischemic injury on NCCT. In the present study, we developed a deep learning (DL) localization model to help localize the early infarction sign on NCCT. This retrospective study included consecutive 517 ischemic stroke (IS) patients who received NCCT within 12 h after stroke onset. A total of 21,436 infarction patches and 20,391 non-infarction patches were extracted from the slice pool of 1,634 NCCT according to brain symmetricity property. The generated patches were fed into different pretrained convolutional neural network (CNN) models such as Visual Geometry Group 16 (VGG16), GoogleNet, Residual Networks 50 (ResNet50), Inception-ResNet-v2 (IR-v2), Inception-v3 and Inception-v4. The selected VGG16 model could detect the early infarction in both supratentorial an

Introduction CSVD refers to a group of clinical, cognitive, imaging, and pathological manifestations caused by structural and functional changes in small vessels including small arteries, arterioles, small venules, venules, and capillary syndrome (1). CSVD is a systemic and whole-brain chronic disease with high recurrence and low mortality rates. Histopathological studies have shown that a narrowed lumen and stiffer walls of the affected vessel hinder blood perfusion and transmural gas transfer (2). There are four main clinical manifestations of CSVD: stroke, cognitive impairment, recurrent lacunar infarction, and white matter lesions (WMLs). Specifically, acute-phase lesions are prone to lacunar infarction and cerebral parenchymal hemorrhage, accounting for 20% of all symptomatic stroke types (3, 4), and chronic-phase lesions show low perfusion and cause persistent and progressive damage to the corresponding brain tissue, including cognitive impairment and dementia, abnormal gait, d