Peripheral Arterial Insufficiency

TUCSON, Ariz. (13 News) - Sudden cardiac arrest is the number one killer of student athletes during exercise. That doesn't mean it's common. When it does happen on the field or the court, as it did when Bronny James collapsed at a USC basketball practice, these frightening events make headlines. Male basketball players suffer from sudden cardiac arrest more often than any other athletes. This stopping of the heart is caused by an irregular heart rhythm - and It can happen to people with no history of heart disease. "First of all, it tends to happen more in men than women. It tends to happen in athletes who are competing at a higher level," said Chief Medical Correspondent Dr. Sanjay Gupta. "Basketball is one of those sports where you tend to see these types of sudden cardiac arrests more and the more minutes that you're playing, the higher likelihood of it happening. Now again, this is rare." Football players are the second most at risk. You may remember...

[unable to retrieve full-text content] 2022 ACC/AHA Guideline for the Diagnosis and Management of ...    AHA Journals

Performing coronary reactivity (CR) testing during angiography in patients with angina without obstructive coronary disease (ANOCA) adds complexity and cost to the procedure but may, in the end, turn out to be a bargain. A retrospective, single-center study suggests that CR testing in ANOCA patients can save money, perhaps a lot of money, probably by helping to limit downstream procedures and other use of health-care resources.  In the retrospective study, CR testing included both adenosine and acetylcholine challenges to differentiate endothelium-dependent from endothelium-independent coronary reactivity as the physiologic cause of ANOCA in individuals. Clarifying the cause at this stage of the patient's clinical journey seemed to sharpen subsequent testing and management decisions, researchers say. Of the 414 patients with ANOCA who underwent invasive diagnostic angiography, 207 also received CR testing during the procedure. The diff...

Cyclarity Therapeutics is striving to make powerful treatments for cardiovascular disease and, most importantly, make them accessible and affordable. Their cutting-edge cyclodextrin technology targets atherosclerosis, aiming to eliminate the buildup of non-degradable oxidized cholesterol that gets stuck inside cells in the arterial walls. The company has made great progress towards launching its cyclodextrin drug for the treatment of atherosclerosis, with human trials set to begin this year. Dr. Matthew 'Oki' O'Connor, CEO of Scientific Affairs at Cyclarity, shares insights about his company's platform, its drug, and his thoughts about the current market.  For people who are not familiar with your work at home, could you tell us a little bit about yourself and your work? My name's Matthew O'Connor, my nickname is Okie, and I'm a biologist. I have a PhD in biochemistry, and I've been studying aging, and that's why I went into science. I've worked ...

[unable to retrieve full-text content] Engineered exosomes reprogram Gli1+ cells in vivo to prevent ...    Science

Emma Egonut, 14, was splashing around in her pool at home when her mother got a frantic call from her pediatrician: Her bloodwork had come back and Emma's kidneys were shutting down. She was rushed to Medical University of South Carolina Shawn Jenkins Children's Hospital and diagnosed with end-stage renal disease. Her mother, Mindy Busse, had no idea what to expect when she got there but immediately noticed the difference in care. "They were there to wrap their arms around us," Busse said. "Some nights the nurses would just come and sit with me." Others are noticing, too.  Shawn Jenkins was recently ranked No. 9 in the Southeast for children's hospitals in the 2023-24 Best Children's Hospital Rankings by U.S. News & World Report, which evaluated nearly 200 children's hospitals. Six of the Charleston hospital...

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