PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy - Science Advances

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy  Science Advances

No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective degradation of ...