Peripheral Arterial Insufficiency

Grant Wahl's wife said that Wahl died from the "rupture of a slowly growing, undetected ascending aortic aneurysm   with hemopericardium." The chest pressure he experienced shortly before his death may have represented the initial symptoms. When the ascending aortic aneurysm ruptures, it ruptures into the pericardium, or the heart sac. Blood accumulates rapidly inside the sac and basically compresses or squeezes the heart so that it can no longer function. This is called pericardial tamponade. This leads to cardiac arrest. Patients with dissection die the same way, usually with pericardial tamponade. John Ritter died of an aortic dissection. It was not clear if dissection was involved in Wahl's death. Adblock test (Why?)

We present the unreported case of a rare association of truncus arteriosus with the ductal origin of the left subclavian artery. Understanding and preoperative identification of these aortic variations are essential to guide optimal surgical management. In this study, the role of advanced visualization 3D modeling techniques in imaging these complex anomalies is discussed. Introduction Truncus arteriosus (TA) is a rare congenital cardiac anomaly with a common trunk that gives rise to the aorta and the main pulmonary artery. TA can be associated with multiple vascular anomalies. An echocardiogram may be limited in the accurate identification of these anomalies. Complex anomalies can be accurately identified using cross-sectional imaging techniques, including computed tomography angiography (CTA) or magnetic resonance angiography (MRA). Advanced post-processing techniques, including volume rendering/3D modeling, may improve the understanding of these malformations. Case Pre

Cyclarity's new head of clinical affairs on targeting atherosclerosis, preclinical progress and accelerating towards clinical trials via new UK regulatory pathway. Biotech start-up Cyclarity Therapeutics has appointed Dr Noah Rosenberg as head of clinical affairs, as the company gears up for clinical trials of novel drugs designed to treat, cure and reverse atherosclerosis. Rosenberg brings more than 20 years' experience in drug development and medical affairs at companies including Pfizer, Sanofi, and Forest Labs, with deep cardiometabolic experience. Longevity.Technology: Cyclarity's appointment of Rosenberg, who has led several successful drug submission teams and launched multiple drugs, is an indication of the company's intentions to begin human clinical trials as quickly as possible. Part of his remit will be to oversee the accelerated drug development under the United Kingdom's Innovative Licensing and Access Pathway (ILAP) , which Cyclarity was one of the

A 54-year-old female patient, Han nationality, BMI: 24.242, History of hypertension in the past, blood pressure up to 150/100 mmHg. In 2016–2018 years, Zhenju antihypertensive tablets to control blood pressure. Stop the drug half a year before surgery by herself-reported. Preoperative paclitaxel + cisplatin two-stage chemotherapy, Nothing special. The patient is admitted to the hospital first time, on January 15, 2018, with "irregular vaginal bleeding for more than 3 months". Gynecological examination found that the patient's cervical canal was thickened with a smooth surface and the neck was translucent with no obvious tumor lesion. The uterine body was enlarged as in the third month of pregnancy, with a smooth surface, and the rest of the examination was unremarkable. Computed tomography (CT) results revealed that there was a mass in the uterine cavity, and the possibility of malignant EC was considered to be high (Fig. 1). MRI confir

Systemic sclerosis (SSc) is a chronic, rare, and idiopathic disease characterized by the presence of microcirculatory and immune alterations followed by fibrosis. It is clinically heterogeneous and may present a rapid and progressive involvement that leads to disability and death. Over the years, the approach has changed with an increasing focus on early diagnosis. Raynaud's phenomenon (RP) and puffy fingers are "red flags" to refer the patients to rheumatology to detect and start the appropriate treatment of such a rare and complex disease. We present a case of a 75-year-old woman with edema and bright erythema on the back and palm of the hands, telangiectasias of the face, and RP with three years of evolution. The aim of this case is to recall the importance of primary care physicians in recognizing the main clinical manifestations of SSc that are sometimes undervalued. Introduction Systemic sclerosis (SSc)/scleroderma

A dermatologist will prescribe medications for atopic dermatitis based upon the severity of disease. "For mild atopic dermatitis, topical steroids and other topical, nonsteroidal, anti-inflammatory medications may be used," says McMichael. Over-the-counter oral antihistamines can help with itch. Corticosteroids . Also known as topical steroids, corticosteroids can take the form of ointment, cream, lotion or spray, according to the National Eczema Association. These medications can reduce inflammation and allow the skin to heal. "This is probably the most common topical treatment and can be used in adults and children," says Wan. Topical steroids are classified by strength, ranging from "super potent" to "least potent." Nonsteroid-Based Topical Treatments Dermatologists may prescribe nonsteroid-based topicals instead of corticosteroids for long-term use, or for cases involving sensitive areas like the face or genitals, says Wan. This group of med

Cite this content as: INTERNATIONAL ATOMIC ENERGY AGENCY, Imaging of Ischemic Heart Disease in Women: A Critical Review of the Literature, IAEA Human Health Series No. 40, IAEA, Vienna (2022) Download to: EndNote BibTeX *use BibTeX for Zotero Adblock test (Why?)

Arteriosclerosis is a chronic degenerative disease It appears especially with advancing age, which causes an increase in the consistency of the vessel wall and can be caused by a variety of disease processes in addition to aging. Several morbid forms are included under this name, which can be found associated or isolated and all of which, however, have as their ultimate effect a more or less reduction in the elasticity of the arterial wall. Arteriosclerosis and the kidneys Arteriolosclerosis affects only organ arterioles and is well documented especially in the kidneys, where it causes a condition known as benign nephrosclerosis. Homogeneous thickening due to deposits of hyaline substance (Hyalinosis) with loss of cellular infrastructure is seen in the affected arterioles. The hyperplastic form is due to proliferation of muscle cells that tighten the lumen; it too frequently affects renal arterioles and is found in cases of severe hypertension sustained by se

Introduction: Coronary artery disease (CAD) is a leading cause of death in developed countries. Non-invasive functional imaging modalities are currently recommended as initial diagnostic tests in patients with an intermediate-high pretest probability of CAD. Single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) creates images of regional myocardial tracer uptake, reflecting relative myocardial blood flow. However, there are other non-perfusion predictors of CAD, such as transient ischemic dilatation (TID) and reduced post-stress left ventricle ejection fraction (LVEF). Available data regarding these parameters is controversial. The aim of our study was to evaluate the incidence of significant CAD in patients with non-perfusion high-risk markers of ischemia despite a normal SPECT-MPI. Methods: Single-center, observational, retrospective, and longitudinal study. Inclusion criteria were age ≥18 years, normal SPECT-MPI, and availability of gated study for

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Abstract The antidiabetic effects of quercetin and metformin are well known. However, their synergistic effect in reversing the symptoms of diabetes-induced endothelial dysfunction remains unknown. In this study, we have investigated their synergistic effect in streptozotocin (STZ)-nicotinamide induced diabetic rats. Seventy-five rats were divided into five groups; normal control, diabetic control, treatment groups (10 mg/kg quercetin, 180 mg/kg metformin, and combined). The plasma glucose and lipid levels, liver enzymes, ex-vivo studies on aortic rings, histology of liver, kidney, pancreas, abdominal aorta and thoracic aorta, and immunohistochemical studies were carried out. The findings revealed that the combination of quercetin and metformin showed a greater antidiabetic effect than either drug, and rendered protection to the endothelium. The combination effectively reversed the hyperglycemia-induced endothelial dysfunction in diabetic rats. Furthermore, it also r