Peripheral Arterial Insufficiency

A cohort study of patients with pulmonary hypertension (PH) has questioned the guideline definition of iron deficiency and the criteria used to identify and potentially treat it, with implications that may extend to cardiovascular disease in general. In the study involving more than 900 patients with PH, investigators at seven US centers determined the prevalence of iron deficiency by two separate definitions and assessed its associations with functional measures and quality of life (QoL) scores. An iron deficiency definition used conventionally in heart failure (HF) — ferritin <100 g/mL or 100-299 ng/mL with transferrin saturation (TSAT) <20% — failed to discriminate patients with reduced peak oxygen consumption (peakVO 2 ), 6-minute walk test (6MWT) results, and QoL scores on the 36-item Short Form Survey (SF-36). But an alternative definition for iron deficiency, simply a TSAT <21%, did predict such patients with re

[unable to retrieve full-text content] Defining Strategies of Modulation of Antiplatelet Therapy in Patients ...    AHA Journals

valve issue symptoms :: Article Creator What To Know About Mitral Valve Disease Mitral valve disease is when the heart's mitral valve stops functioning correctly. This can lead to blood not flowing around the body correctly and cause several health complications. The mitral valve resides in the heart between the upper left chamber, known as the left atrium, and the lower left chamber, known as the left ventricle. The primary function of the mitral valve is to allow the normal flow of blood from the left atrium to the left ventricle and to stop blood from going in the wrong direction. This article discusses the different types of mitral valve disease, symptoms, causes, and treatment options that may be available. Mitral valve disease occurs when the mitral valve in the heart suffers from damage or disease and stops functioning correctly. This means the heart has to work harder, and a person may feel tired or breathless. Ther

the heart :: Article Creator Aloha Heart: Release Date, Cast And Everything We Know About The Hallmark Channel Movie Taylor Cole and Kanoa Goo in Aloha Heart It's time to say goodbye to Christmas in July 2023 and "aloha" to the rest of the summer with Aloha Heart, an all-new original Hallmark Channel movie. Fire Country's Kanoa Goo plays Manu, a proud Hawaiian whose focus on conservation is often at odds with his family's hotel business. Taylor Cole plays Sara, who is in Hawaii for her best friend's wedding, taking place at Manu's hotel. They don't get off on the best foot but soon they discover that they're actually a great team. Here's what we know about Aloha Heart. Aloha Heart release date Aloha Heart premieres Saturday, July 29, at 8 pm ET/PT on Hallmark Channel. As of this writing, there's no release date for the movie in the UK, but as soon as one is available we'll add that inf

Abstract The current understanding of the genetic determinants of thoracic aortic aneurysms and dissections (TAAD) has largely been informed through studies of rare, Mendelian forms of disease. Here, we conducted a genome-wide association study (GWAS) of TAAD, testing ~25 million DNA sequence variants in 8,626 participants with and 453,043 participants without TAAD in the Million Veteran Program, with replication in an independent sample of 4,459 individuals with and 512,463 without TAAD from six cohorts. We identified 21 TAAD risk loci, 17 of which have not been previously reported. We leverage multiple downstream analytic methods to identify causal TAAD risk genes and cell types and provide human genetic evidence that TAAD is a non-atherosclerotic aortic disorder distinct from other forms of vascular disease. Our results demonstrate that the genetic architecture of TAAD mirrors that of other complex traits and that it is not solely inherited through protein-altering variants of large

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